The Serene protocol
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The science behind the Protocol
Calmer focus by day. A softer landing at night.
The Protocol works both sides of that conversation: a morning formula for the day side, an evening formula for the night side, and a published human trial behind every active in both.
Follow the scienceSo the Protocol solves them separately. Both formulas share the same synbiotic foundation. What changes is the layer on top, and the job it does.
Bimuno® GOS is a prebiotic: the food beneficial gut bacteria use. L. plantarum DR7 is a single named strain studied for how it supports gut-brain axis function. Together they are a complementary synbiotic, two ingredients each carrying its own human evidence, in both formulas.
Every serving carries 1.39 g of active GOS and 1 billion CFU of DR7. Across your morning and evening servings that is at least 2.75 g of active GOS a day.
Most things that take the edge off also take the edge off your thinking. L-theanine does not work that way. Daily Calm Focus carries 200 mg, the amount studied for a calm but attentive mental state, alongside a full B-complex in active forms that supports energy metabolism.
Magnesium is not one ingredient. Most products use oxide because it is the cheapest, and it is the reason magnesium has the reputation it does. Nightly Rest & Restore uses bisglycinate, magnesium bound to glycine, at 200 mg of elemental magnesium in every evening serving.
Daily Calm Focus. Bimuno® 1.83 g, delivering 1.39 g active GOS. L. plantarum DR7, 1 billion CFU. L-theanine 200 mg. Thiamin 25 mg. Riboflavin 15 mg. Pantothenic acid 50 mg. Vitamin B6 as pyridoxal-5-phosphate 10 mg. Vitamin B12 as methylcobalamin 250 mcg.
Nightly Rest & Restore. Bimuno® 1.83 g, delivering 1.39 g active GOS. L. plantarum DR7, 1 billion CFU. Magnesium as magnesium bisglycinate, 200 mg elemental.
These four are the ones that decided the formulas.
Study 01
Bimuno® GOS
By the end of week one, mean bloating, flatulence, and abdominal-discomfort scores were lower than both baseline and placebo. The difference held at week two. One Protocol serving carries 1.39 g of active GOS; the trial used 1.37 g a day.
Study 02
L. plantarum DR7
In 111 adults with moderate stress, DASS-42 stress scores were lower than placebo at week eight. Both Protocol formulas carry the same 1 billion CFU of DR7 that trial used.
Study 03
L-theanine
Sixty minutes after a timed mental-arithmetic challenge, salivary cortisol dropped further with 200 mg of L-theanine than with placebo. This is the acute response: the spike, and how fast it settles. Daily Calm Focus carries 200 mg of L-theanine. The trial used AlphaWave® branded L-theanine.
Study 04
Magnesium bisglycinate
In 155 adults reporting poor sleep, magnesium bisglycinate improved self-rated sleep quality more than placebo over four weeks. Nightly Rest & Restore carries 200 mg of elemental magnesium in that same bisglycinate form.
Certifications and testing details will be listed on the product page at launch.
The research on this page was selected and translated by named people, with medical perspective from our Medical Advisor.
Two formulas, morning and evening. A prebiotic, a named probiotic strain, L-theanine, and magnesium bisglycinate, each with a published human trial behind it. Preorder the two-part daily routine. A welcome kit is included with early orders, while supplies last.
Bimuno® is a trademark of Clasado Limited.
