A protocol works
when you stay with it.

The gut-brain base builds over weeks, not days. A subscription is how you give it those weeks.

Start your protocol See the plans

Subscriptions are open. Charged today; your first box ships Fall 2026, then renews at the cadence you chose until you cancel.

Why subscribe

Never run out. A daily protocol only works if it is daily. Your next box arrives before you finish this one.
A better price than buying one box at a time, deeper the longer you commit.
Full control. Skip, pause, or cancel anytime, in a click. No phone call, no friction.

Consistency is the active ingredient.

You feel the L-theanine the first morning. The probiotic and the prebiotic work on a slower clock, one that only counts the days you actually take it. That is the whole case for subscribing.

01

Built for the weeks that matter

The probiotic and prebiotic build the gut-brain base over weeks two to eight. Miss days in the middle of that build and you give back progress you already paid for. A subscription keeps the days unbroken.

02

Subscribers pay the lowest price we offer

Every subscription price sits below the one-time price, and prepaying three or six months goes lower still. A protocol you take for months should not cost the same as a box you try once.

03

One less decision

Your morning and evening formulas just show up before you finish the last box. No reorder to remember, no gap in the routine, no drawer of half-used bottles. The ritual runs itself.

The best results live past week four.

Here is the morning protocol's honest arc. The deepest support arrives in the weeks most people never reach on a single box. A subscription is how you get there.

See the full timeline
Day 1The first sips

Calm focus within about an hour

L-theanine in the morning formula is felt the same day.

Week 1Settling in

Digestive comfort can begin

The Bimuno prebiotic starts its work as your gut adjusts.

Weeks 2-4The base builds

Where the slow work happens

The probiotic and prebiotic compound, day after day.

Weeks 4-8Full stride

Stress resilience builds

The window most single boxes never reach. This is where staying pays off.

How long do you want to give it?

Every plan ships the same precision-dosed formulas at the same amounts. What changes is how long you stay with it. Start with one formula, or take the full morning-and-evening protocol.

Monthly subscription

Both formulas · renews monthly

$98.10/ month

Monthly flexibility

$98.10/mo ($3.27/day), charged today. Renews until you cancel.

  • Peach Mango + Hibiscus Vanilla, every month
  • Bimuno GOS in both servings, the fiber that feeds the probiotic
  • Skip, pause, or cancel anytime
Start this plan

Charged today; ships Fall 2026. Cancel before it ships for a full refund.

Recommended

3-month subscription

Both formulas · billed every 3 months

$87.20/ month

Recommended · welcome kit included

$87.20/mo ($2.91/day), billed $261.60 every 3 months.

  • Three months, the weeks the protocol is built around
  • A fresh box still arrives each month
  • The $130 welcome kit, free in box one
  • 30-day Gut-Brain Protocol guarantee
Start this plan

Charged today; ships Fall 2026. Cancel before it ships for a full refund.

6-month subscription

Both formulas · billed every 6 months

$81.75/ month

Best value · welcome kit + bonus month

$81.75/mo ($2.73/day), billed $490.50 every 6 months.

  • Six months at the lowest per-month price
  • A fresh box still arrives each month
  • The $130 welcome kit in box one, plus a free bonus month
  • 30-day Gut-Brain Protocol guarantee
Start this plan

Charged today; ships Fall 2026. Cancel before it ships for a full refund.

Choose a one-time order or an auto-renewing subscription. You are charged today and your first box ships Fall 2026; subscriptions then renew at the cadence you chose until you cancel. Cancel online any time before it ships for a full refund, or any time after to stop future renewals.

We would rather send you something than shave the price.

Choose a 3-month or 6-month founding subscription and your first order includes the welcome kit, a $130 value: a cap, insulated bottle, and vegan-leather pouch.

  • Founding capA plain, well-made cap for the people who got here first.
  • Insulated bottleMade for the morning and evening pour.
  • Vegan-leather pouchKeeps your formulas ready at home or on the move.

The full welcome kit, a $130 value, is included with the first order of the 3-month and 6-month plans.

Start a subscription
The Serene Biotics welcome kit: cap, insulated bottle, and vegan-leather pouch in a teal keepsake box

The kit starts at three months, and six months adds a month back.

The formulas are identical in every plan. What changes is what arrives beside them in box one: the $130 welcome kit on the 3-month and 6-month plans, plus a free month of the protocol on the 6-month.

Monthly plan

Flexible

Month to month

Best if you want the smallest first commitment

  • First box ships Fall 2026
  • Charged today
  • Renews monthly until canceled

Cancel before your first shipment for a full refund.

3-month subscription

Recommended

Full welcome kit

A $130 value, free in box one

  • Cap
  • Insulated bottle
  • Vegan-leather pouch

Billed every 3 months.

6-month subscription

Best value

Full welcome kit + bonus month

A $130 value kit, free in box one

  • Cap, insulated bottle, and vegan-leather pouch
  • Lowest per-month protocol price
  • Plus a free bonus month of the protocol, on top

Billed every 6 months.

One welcome kit per customer, included with the first 3-month or 6-month subscription order.

The amount only counts on the days you take it.

at least

2.75 g

of Bimuno GOS prebiotic fiber a day

A probiotic only does its work if something feeds it, and Bimuno GOS is the fiber that feeds the DR7 strain in both formulas. Every serving carries 1.39 g of it, morning and evening. Vulevic 2018 studied Bimuno GOS at 1.37 g a day in 91 adults with frequent bloating, flatulence, or abdominal pain.

A Daily Calm Focus stick pack beside the prepared golden drink
A Daily Calm Focus stick pack beside the prepared golden drink

You are in control the whole way.

There is no contract and no penalty for changing your mind.

Skip a delivery

Heading out of town or still stocked up? Skip your next box and the schedule picks back up after. Nothing wasted.

Pause anytime

Need a break? Pause your subscription for as long as you like and restart whenever you are ready. Your founding-member price holds.

Cancel in a click

Change your mind? Cancel yourself from your account in seconds. No phone call, no retention maze, no hard feelings.

At 3, 6, and 12 months in, a small gift arrives. Nothing to claim, no threshold to hit, no strings attached. It is how we mark the time you have stayed.

30day guarantee

Long enough to know whether your mornings changed.

Take it for a month and decide for yourself.

The gut-brain side builds over weeks, so a few days tells you nothing. Take both formulas daily for the full 30 days. If it has not earned its place in your routine by then, you are covered.

It covers every plan, one-time, monthly, and multi-month, for 30 days from the day your first order is delivered.

Read the full refund policy

Start the protocol at founding-member pricing.

The protocol ships Fall 2026. Join for founder updates from the lab and first access when auto-renewing subscription reservations open.

No spam. Founder updates and your founding-member offer at launch. Free to join.