Calm focus by day.
Restful sleep by night.

Both formulas work on the gut-brain connection, at the doses the research used. No caffeine, no melatonin.

The Daily Calm Focus and Nightly Rest and Restore cartons
  • 47published human trials
  • 5named actives, each at its studied dose
  • 2.75 gof prebiotic fiber a day, at least

Take both, or start where your day needs it most.

Daily Calm Focus carton beside a prepared morning drink
MorningPeach Mango

Daily Calm Focus

Steady focus without caffeine, and without the crash that follows it. 30 servings.

Plans from $62.99/mo
View morning plans
Nightly Rest and Restore carton beside a prepared evening drink
EveningHibiscus Vanilla

Nightly Rest & Restore

Wind down without melatonin, and wake without the fog it can leave. 30 servings.

Plans from $62.99/mo
View evening plans
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Save 20%3-month protocol

$87.20/mo · $261.60 charged every 3 months · welcome kit included

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One minute, twice a day.

Stir one serving into cool water when you wake, one more when the day is done. No pill organizer, no stack to manage.

A hand setting down a prepared Daily Calm Focus drink
Morning · Daily Calm Focus

Clear, steady mornings.

200 mg of L-theanine, the amount published trials used, plus an active B-complex.

A hand holding a prepared Nightly Rest and Restore drink
Evening · Nightly Rest & Restore

A quieter close.

Most of the category uses magnesium oxide. This one uses bisglycinate, 200 mg elemental, every evening.

When digestive comfort begins Bimuno® GOS, 1.37 g · Vulevic 2018, n=83Baseline StartLess bloating, gas & abdominal discomfort p < 0.001 vs placebo Week 1Comfort sustained Week 2 A 7-week randomized, placebo-controlled crossover trial at 1.37 g a day.

In a 7-week randomized, placebo-controlled trial (Vulevic 2018, n=83, at the 1.37 g dose), the clinically studied Bimuno® GOS prebiotic supported digestive comfort, with less bloating, gas and abdominal discomfort vs placebo by the first week (p < 0.001), sustained through week 2. Bimuno® is a trademark of Clasado Limited.

The probiotic comes with the fiber that feeds it.

Bimuno GOS is that fiber, at 1.39 g in every serving. The probiotic beside it is L. plantarum DR7, a named strain from Kaneka. No finished-product trial exists.

1.39 g
Bimuno® GOS per serving
1B CFU
L. plantarum DR7, the Kaneka strain, per serving
200 mg
L-theanine, the amount published trials used
200 mg
elemental magnesium, as bisglycinate
Release standard No lot will ship until Eurofins clears it. Explore the evidence
Serene Biotics co-founders and medical advisor

Three people put their names on this.

Formulation, brand, and medical review each sit with one named person here. If something in this protocol is wrong, you know exactly who to ask.

Per Rehne
Co-founder & Product Development Advisor
Ida Adams
Creative Co-founder
Dr. Yashaswini Yeragunta, MD
Medical Advisor
Meet the team

Before you order.

When will my pre-order ship?

Founding orders are estimated to ship Fall 2026. You are charged when you place the pre-order and can cancel for a full refund before it ships.

How do I take the protocol?

Mix one Daily Calm Focus serving into cool water in the morning and one Nightly Rest & Restore serving into cool water in the evening.

Does either formula contain caffeine or melatonin?

No. Daily Calm Focus is caffeine-free, and Nightly Rest & Restore is melatonin-free.

What should I know before taking it?

Both formulas contain milk. If you are pregnant or nursing, take medication, have a medical condition, or are considering the protocol for anyone under 18, speak with a qualified clinician before use.

How do subscriptions renew?

Your selected recurring price, billing cadence, first-charge timing, and cancellation terms are shown before checkout. You can manage future renewals from your account.

What are the guarantee and shipping terms?

A 30-day money-back guarantee applies to your first order and starts the day it is delivered. U.S. shipping is free on every order.

The Serene Biotics welcome kit with the complete Gut-Brain Protocol

Start the protocol.

Both cartons ship together with the founding welcome kit. Cancel before they leave the warehouse for a full refund, and the 30-day guarantee starts the day they arrive.

$87.20/mo
Choose 3-month plan Estimated to ship Fall 2026
Complete protocol · 3-month plan$87.20/mo Pre-order